Grounding layer for precision oncology agents

AI that validates every biomarker, before it reaches a tumor board.

Every fact grounded to a source, never guessed.

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General AIuncited · not reproducible

This is EGFR L858R (c.2573T>G, p.Leu858Arg), a well-known activating mutation in exon 21. It confers sensitivity to EGFR tyrosine-kinase inhibitors such as gefitinib, erlotinib, and osimertinib. Classified as oncogenic; corresponds to COSMIC ID COSM6224 and is typically Tier IA.

run #1
Clarus✓ PASS
HGVS
NM_005228.5:c.2573T>G
protein
p.Leu858Arg
tier
ESCAT I-A
cite
CIViC EID275 (Level B)
region
FDA (US) · EMA (EU)

last updated 2026-07-13

Clarus stays consistent while General AI drifts

Demo

Watch a raw output become a validated report.

How it works

A framework you can trust.

Traceable, inspectable, auditable.

  1. 1

    ingest

    Raw sequencing output or PDF, with the reference build (GRCh38) confirmed.

  2. 2

    classify

    Oncogenicity by VICC / CGC criteria, not model opinion.

  3. 3

    actionability

    ESCAT tier and matched therapy, cited to a CIViC evidence item.

  4. 4

    validate

    Every LOINC / SNOMED CT / HGNC code resolved against the terminology validation.

  5. 5

    assemble

    mCODE-conformant FHIR GenomicsReport.

Usability

Grounded, not guessed.

We flag it for a human and it does not fill the gap with a confident-sounding guess.

We don't guess, we check.

Every result — which gene, which mutation, which drug — is checked against a trusted medical source first. If we can't confirm it, we don't show it.

Fits into how you already work

Integrate the framework into existing workflow seamlessly, human-in-the-loop.

Inspectable, end to end

Reproducible byte-for-byte. Detailed tracing and citing for regulatory approval.

Human validation

Every report is signed by a human.

The Clarus framework is human-in-the-loop by design. The reviewer sees each criterion and its justification, then accepts, overrides, or flags it. The report only leaves the system once a person has signed it.

The Clarus review dashboard: per-variant VICC quality metrics with each criterion's strength, points, status, source and justification; and the EHR integration view with grounded genomic findings and clinical-trial matching marked Pass or Indeterminate.
Disclaimer: Illustrative overview, not medical advice.

Every criterion shows its source

Each VICC criterion carries its strength and authoritative source it came from, auditable line by line.

Nothing is emitted until it passes

Approval stays disabled until the report clears validation. What cannot be grounded is held to be reviewed or marked Indeterminate.

The sign-off is recorded

The reviewer accepts or overrides with a rationale. Their attestation is written into a FHIR Provenance record. There is no auto-emit.

Dual-audience

Built for labs and agents.

Use it as a building block, we set it up with you.

Software for Agents

Composable guide for your agents and cite output your agent orchestration can trust.

Partner with Us

See Clarus on your workflow.

We're onboarding design partners, labs, industry, and teams building clinical-grade agents. Tell us what you would run, and we will set up.